Watermelon Fungicide Guide for 2025

The information provided below is current at this time. If any updates are made to the information below, the corresponding year in which the updates are made will be included in the publication title.

Four foliar diseases reduce watermelon yields in South Carolina. Gummy stem blight and powdery mildew are the most common diseases in spring crops.¹

Gummy stem blight is large, round spots on the edges of leaves and dry cankers on the main stem (figure 1). The best fungicides are Miravis Prime or Inspire Super. Powdery mildew is yellow spots on the top of leaves and white powdery mildew on the bottom (figure 2). It shows up during dry periods. The best fungicides are Gatten or Vivando. The new fungicide Prolivo is not recommended because it is less effective on the bottom of leaves than other powdery mildew fungicides.²

Figure 1. Gummy stem blight. Image Credit: Anthony P. Keinath, Clemson University.

Figure 2. Powdery mildew. Image Credit: Anthony P. Keinath, Clemson University.

Downy mildew starts as brown or yellow, round or irregular spots that spread quickly (figure 3). If seen, spray immediately with Ranman or Orondis Ultra, followed by the other fungicide the following week. Anthracnose starts as dark, irregular spots with points like a star (figure 4). It also affects vines and young fruit. The best fungicides are Evito, Flint, Cabrio, mancozeb, or chlorothalonil.

Figure 3. Downy mildew. Image Credit: Anthony P. Keinath, Clemson University.

Figure 4. Anthracnose. Image Credit: Anthony P. Keinath, Clemson University.

Scouting for Diseases

• Walk fields weekly and the day before spraying.
• Yellow spots on leaves are symptoms of powdery mildew or downy mildew. Look for spores on the underside of leaves in the early morning. Call your local Clemson Cooperative Extension county office if you can’t identify the disease. County office contact information is available on the Cooperative Extension website.
• Brown spots are usually gummy stem blight or anthracnose. Anthracnose also shows up as tan, narrow, sunken spots on vines.

How to Get the Most Out of Spraying

Table 1 provides details for fungicide spray programs for spring and fall crops. Follow these steps to get the most out of your fungicide program.

• Rotate fields to crops other than cucurbits for two years in between watermelon and cantaloupe to help control gummy stem blight and anthracnose.³
• Start spraying when vines start to run (12 inches long), no later than when the first (male) flowers open.
• From vine run until mid-May, spray every seven to ten days.
• After mid-May, spray every week through harvest regardless of the weather. Powdery mildew can attack under dry conditions with morning dews providing sufficient moisture for rapid spread.
• All watermelon diseases can attack any time a crop goes more than a week without a fungicide.
• Apply fungicides, allowing time to dry, before a predicted rain rather than after.
• For best control after disease starts, use systemic fungicides (see option “b” in the first column of table 1).
• Do not stop spraying until one week before the final picking.⁴

Fungicide Programs

• The spring watermelon fungicide program is designed to manage bacterial fruit blotch, bacterial leaf spot, gummy stem blight, powdery mildew, anthracnose, and downy mildew.
• The fall program is designed to manage gummy stem blight, downy mildew, anthracnose, and powdery mildew.
• Chlorothalonil and mancozeb protect against gummy stem blight, downy mildew, and anthracnose; chlorothalonil also protects against powdery mildew.
• Week-by-week rotation is built into the spray programs for systemic fungicides, like Miravis Prime, to reduce the risk of fungicide resistance.
• Inspire Super has a 7-day pre-harvest interval (PHI) on watermelon. This fungicide should not be sprayed after harvesting starts. When harvest begins before nine weeks after transplanting, skip ahead to spray number 6a or 6b listed in table 1. Mancozeb and Gavel have a 5-day PHI.
• See the current edition of the “Southeastern U.S. Vegetable Crop Handbook” for more information.⁵

Resistance to Tebuconazole

Since 2019, most (93%) samples of the gummy stem blight fungus collected from watermelon crops in South Carolina are moderately resistant to tebuconazole, the active ingredient in Monsoon, Folicur, and other products. ⁶ Only 3% of the samples were sensitive, and 4% were highly resistant. The frequency of moderately resistant samples on seven farms was 69% to 100%.

Moderately resistant isolates were only 70% controlled by tebuconazole in greenhouse tests. If tebuconazole is sprayed, 30% of the treated foliage will likely develop gummy stem blight. Continued use of tebuconazole will lead to a highly resistant fungus, which means control is only 45%. Widespread resistance is why tebuconazole is not recommended in the 2025 update.

Table 1. Weekly fungicide guide for watermelon.

*Fungicides for downy mildew are bolded and should be used if downy mildew has been reported on watermelon in the current season (check the Cucurbit Downy Mildew Forecasting website [cdm.ipmpipe.org/]). Fungicides for powdery mildew are underlined and should be applied all spring and during dry periods in the Fall. Cantaloupe growers using this fungicide program can omit underlined fungicides for powdery mildew on hybrid varieties.

**Option “a” is a lower cost treatment that may be less effective. Option “b” is a more expensive systemic fungicide that is more effective when disease is already in the field or when weather conditions favor disease getting worse.

References Cited

1. Rennberger G, Gerard P, Keinath AP. Occurrence of foliar pathogens of watermelon on commercial farms in South Carolina estimated with stratified cluster sampling. Plant Disease 2018 Nov. 102(11):2285–2295.https://apsjournals.apsnet.org/doi/10.1094/PDIS-03-18-0468-RE.
2. McGrath MT, Sexton ZF. Efficacy of fungicides for managing powdery mildew in pumpkin, 2016. Plant Disease Management Reports. 2017;11:V024. https://www.plantmanagementnetwork.org/pub/trial/pdmr/reports/2017/V024.pdf 
3. Rennberger G, Gerard P, Keinath AP. Factors influencing the occurrence of foliar pathogens in commercial watermelon fields in South Carolina based on stratified cluster sampling. Plant Disease 2019 Mar;103(3):484–494. https://apsjournals.apsnet.org/doi/10.1094/PDIS-07-18-1188-RE.
4. Keinath AP. Effect of protectant fungicide application schedules on gummy stem blight epidemics and marketable yield of watermelon. Plant Disease 2000 Mar;84(3):254–260. https://doi.org/10.1094/PDIS.2000.84.3.254
5. Kemble JM, senior editor. Albornoz K, Bertucci MB, Bilbo TR, Jennings KM, Meadows IM, Melanson RA, Rodrigues C, Rudolph RE, Wright-Smith HE, Walgenbach JF, Wszelaki AL, associate editors. 2025 Southeast U.S. vegetable crop handbook. 2025. www.vegcrophandbook.com.
6. Keinath, AP, Rennberger, G, Wechter, WP. Widespread resistance to tebuconazole and cross-resistance to other DMI fungicides in Stagonosporopsis citrulli isolated from watermelon in South Carolina. Plant Disease 2023 Dec 107(12):3896–3905. https://doi.org/10.1094/PDIS-03-23-0478-RE.

Additional Resources

Keinath AP. Cucurbit downy mildew management for 2022. Clemson (SC): Clemson Cooperative Extension, Land-Grant Press by Clemson Extension. 2022; LGP 1002. http://lgpress.clemson.edu/publication/cucurbit-downy-mildew-management.

Keinath AP, Rennberger G. Powdery mildew on watermelon. Clemson (SC): Clemson Cooperative Extension, Land-Grant Press by Clemson Extension. 2022; LGP 1019. http://lgpress.clemson.edu/publication/powdery-mildew-on-watermelon.